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Volume 32 , Issue 3
June 2012
Pages 263-271

Growth Factor–Mediated Combination Therapy to Treat Large Local Human Alveolar Ridge Defects

Myron Nevins, DDS/Marcelo Camelo, DDS/Marc L. Nevins, DMD, MMSc/Daniel K. Ho, DMD, MSc/Peter Schupbach, PhD/David M. Kim, DDS, DMSc

PMID: 22408770
DOI: 10.11607/prd.00.1068

The purpose of this case report is to demonstrate the effectiveness of a matrix consisting of recombinant human platelet-derived growth factor BB (rhPDGF-BB)–hydrated cancellous allogenic block graft in the reconstruction of large local human alveolar ridge defects. The results suggest improved bone regeneration when combining rhPDGF-BB with the allogenic block graft. The clinical and histologic evidence of new bone formation as well as bone remodeling supports the clinical potency of this growth factor–mediated therapy. (Int J Periodontics Restorative Dent 2012;32:263–271.)

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